M22

M22 is a cryoprotectant that the Alcor Life Extension Foundation uses in vitrification. Developed by 21st Century Medicine, M22 replaced B2C, a vitrification solution that Alcor had used until 2005. The glass transition temperature of M22 is −123 °C. The name of M22 refers to minus 22 degrees Celsius, which is the temperature at which the full-strength solution is perfused into kidneys in published organ cryopreservation experiments.

M22 concentrate for whole-body preservation and M22 concentrate for neuropreservation are not the same. M22 concentrate for whole-body patients has an additional component to mitigate edema during perfusion.

The first person vitrified with M22 is A-2071, a whole-body patient who was cryopreserved by Alcor in August 2005. A-1598, who was cryopreserved in October 2005, is the first neuropreservation patient vitrified with M22.